Value of tumor-associated CD66b-positive neutrophils for the prediction of the recur-rence of stage Ib and IIa cervical cancer
10.3969/j.issn.1000-8179.2017.21.598
- VernacularTitle:肿瘤相关CD66b阳性中性粒细胞对预测宫颈癌Ⅰb至Ⅱa期复发的价值
- Author:
YAN BIN
1
;
CHEN HUIJUN
;
GAO HAN
;
TAN WENFU
;
CAI HONGNING
;
ZHOU ZHIGANG
;
DAI XUAN
;
ZHU FAXIA
;
XIONG YUJING
Author Information
1. 湖北省妇幼保健院肿瘤妇科 武汉市430070
- Keywords:
cervical cancer;
prognosis;
neutrophil;
recurrence
- From:
Chinese Journal of Clinical Oncology
2017;44(21):1071-1075
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognostic effect of polymorphnuclear neutrophil (PMN) in cervical cancer. Methods:Patients (n=92) who underwent curative surgery for the treatment of stage Ib and IIa cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) were assessed to determine their tumor-infiltrating CD66b-positive neutrophils through immuno-histochemistry. Assessment results were then analyzed to identify their correlation with recurrence-free survival (RFS) as an end point. Kaplan-Meier method was used for survival curve analysis, and a Cox proportional hazard model was utilized for univariate and multi-variate analyses. Results:The RFS of the group with a density of CD66b-positive neutrophils above the median in cervical cancer tis-sues was significantly shorter than that of the group with a density of CD66b-positive neutrophils below the median (P=0.001). Univari-ate and multivariate analyses revealed adenocarcinoma (HR=3.020;95%CI=1.340-6.805;P=0.008), lymph node metastasis (HR=2.450;95%CI=1.065-5.637;P=0.035), and high neutrophil density (HR=2.866;95%CI=1.274-46.447;P=0.011) as independent prognostic fac-tors of short RFS. Conclusion:The increasing number of tumor-infiltrating neutrophils in cervical cancer tissues was correlated with short RFS of patients with cervical cancer.
