Pathogenesis of portal hypertensive gastropathy in cirrhotic patients and the application of antacids in treatment

VernacularTitle:肝硬化门静脉高压性胃病的发病机制及抗酸剂的治疗应用
Author: Zongguo YANG ¹ ; Jianliang ZHANG
Author Information

1. 上海市公共卫生临床中心
Keywords: portal hypertensive gastropathy; liver cirrhosis; antacids; review
From: Journal of Clinical Hepatology 2017;33(11):2218-2221
CountryChina
Language:Chinese
Abstract: Portal hypertensive gastropathy (PHG) has a high incidence rate in cirrhotic patients,leading to a high risk of upper gastrointestinal bleeding.Gastric mucosal injury is the major pathological change of PHG.There are few studies focusing on the clinical application of antacids in the treatment of PHG in cirrhotic patients and there are still controversies over this issue.This article reviews the influencing factors for PHG,the mechanism of gastric mucosal injury,and the application of antacids.It is pointed out that during the treatment of PHG,besides the reduction in portal venous pressure,the application of antacids such as proton pump inhibitors can improve the cure rate of PHG.Prospective randomized control trials with a large sample size are needed to further demonstrate the clinical effect and safety of antacids in the treatment of PHG in cirrhotic patients.