Research advances in immunoglobulin G4-related sclerosing cholangitis
10.3969/j.issn.1001-5256.2017.11.042
- VernacularTitle:IgG4相关性硬化性胆管炎的研究现状
- Author:
Yuhan LI
1
;
Xiaoxing XIANG
Author Information
1. 大连医科大学消化内科
- Keywords:
immunoglobulin G;
cholangitis,sclerosing;
review
- From:
Journal of Clinical Hepatology
2017;33(11):2239-2242
- CountryChina
- Language:Chinese
-
Abstract:
Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) is a new type of secondary sclerosing cholangitis which was discovered recently and has unknown pathogenesis.IgG4-SC is characterized by an increased serum level of immunoglobulin G4 (IgG4),chronic progressive obstructive jaundice,diffuse or local infiltration of a large number of IgG4-positive plasma cells and lymphocytes,fibrosis,and obstructive phlebitis.This article reviews the diagnosis and treatment of IgG4-SC and its association with primary sclerosing cholangitis and cholangiocarcinoma.
