Clinical effects and safety comparison of two kinds of sufentanil doses combined with ropivacaine for analgesia on painless childbirth
10.3760/cma.j.issn.1008-6706.2017.24.011
- VernacularTitle:无痛分娩中两种剂量舒芬太尼联合罗哌卡因镇痛效果及安全性比较
- Author:
Hongfu CHEN
1
;
Lanfeng CHEN
;
Shaojun ZHU
Author Information
1. 舟山市妇幼保健院麻醉科
- Keywords:
Analgesia,obstetrical;
Dose-response relationship,drug;
Sufentanil;
Ropivacaine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(24):3724-3727
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinical effects and safety differences of conventional and low doses of sufentanil combined with ropivacaine for analgesia on painless childbirth.Methods 130 lying-in women with painless childbirth were chosen and randomly divided into two groups including control group (65 cases) with sufentanil for 7.5μg and observation group (65 cases) with sufentanil for 5.0p g combined with ropivacaine;the block onset time,the arrival time at the maximum block level,modified Brcmage score,the Apgar score in 5min after childbirth,the VAS score before and after analgesia and adverse reaction incidence of both groups were compared.Results The sense and motion block onset time and the arrival time at the maximum block level of control group were separately (4.33 ± 1.91) min,(7.50 ± 1.70) min,(14.26 ± 1.50) min.The sense and motion block onset time and the arrival time at the maximum block level of observation group were separately (3.68 ± 1.54) min,(5.73 ± 1.21) min,(9.71 ± 1.15)min.The block onset time and the arrival time at the maximum block level of observation group were significant shorter than control group (t =2.78,3.07,3.47,all P ＜ 0.05).The modified Bromage score of observation group were significant lower than control group (t =2.92,P ＜ 0.05).There was no significant difference in the Apgar score in 5min after childbirth between the two groups(t =1.29,P ＞0.05).There was no significant difference in VAS score before and after analgesia between the two groups (t =1.15,1.02,0.95,0.63,0.87,all P ＞ 0.05).The adverse reaction incidence of observation group were significant lower than control group (x2 =9.24,8.66,12.07,10.45,all P ＜ 0.05).Conclusion Compared with conventional doses of sufentanil,low doses of sufentanil combined with ropivacaine for analgesia on painless childbirth can efficiently accelerate the block onset process and reduce the risk of adverse reactions.
