Influence of probiotics assisted with routine antibiotic regimens on the short-term clinical efficacy, mucosal barrier function and inflammatory response of patients with bacterial peritonitis secondary to liver cirrhosis
10.3760/cma.j.issn.1008-6706.2017.24.020
- VernacularTitle:益生菌辅助常规抗生素方案治疗肝硬化继发细菌性腹膜炎的临床研究
- Author:
Gang LIN
1
;
Meijin HU
;
Chunying YANG
;
Maosen LIU
Author Information
1. 台州市中心医院消化内科
- Keywords:
Probiotics;
Peritonitis;
Cirrhosis;
Anti-infective ageuts
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(24):3754-3757
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of probiotics assisted with routine antibiotic regimens on the short-term clinical efficacy,mucosal barrier function and inflammatory response of patients with bacterial peritonitis secondary to liver cirrhosis.Methods 60 patients with bacterial peritonitis secondary to liver cirrhosis were chosen,and they were randomly divided into two groups according to the digital table,each group in 30 cases.The control group received routine antibiotic regimens alone,and the observation group were given probiotics on the basis of the control group.The short-term clinical efficacy,the levels of DAO,D-Lac and ET before and after treatment of the two groups were compared.Results The short-term effective rates of the control group and observation group were 70.00％,96.67％,respectively.The short-term effective rate of the observation group was significantly higher than that of control group(x2 =9.14,P ＜0.05).After treatment,the levels of DAO of the control group and observation group were (4.33 ± 0.79) U/mL,(2.19 ± 0.47) U/mL,respectively.The levels of D-Lac of the control group and observation group after treatment were (15.88 ± 1.95) U/mL,(8.57 ± 1.03) U/mL,respectively.The levels of DAO and D-Lac of the observation group after treatment were significantly lower than those of the control group and before treatment(t =2.78,3.06;3.44,3.78,3.61,4.10,all P ＜ 0.05).The levels of ET of the control group and observation group after treatment were (0.09 ± 0.02) EU/mL,(0.04 ± 0.01) EU/mL,respectively.The level of ET of the observation group after treatment was significantly lower than that of the control group and before treatment(t =2.49,3.01,3.46,all P ＜ 0.05).Conclusion Probiotics assisted with routine antibiotic regimens in the treatment of patients with bacterial peritonitis secondary to liver cirrhosis can effectively relieve the symptoms and signs,improve the mucosal barrier function and is helpful to reduce the inflammatory response.
