CTA and fundus imaging in observation of relationship between internal carotid artery stenosis and retinal vascular calibers
10.13929/j.1003-3289.201706067
- VernacularTitle:基于CTA和眼底成像观察颈内动脉狭窄程度与视网膜血管管径的关系
- Author:
Ling ZHANG
1
;
Zhenchang WANG
;
Pengfei ZHAO
;
Yanling WANG
;
Xiaojie ZHANG
;
Hongyang LI
;
Rui LI
;
Hui WANG
;
Peng WANG
Author Information
1. 首都医科大学附属北京友谊医院放射科
- Keywords:
Carotid artery,internal;
Stenosis;
Retinal vessels;
Tomography,X-ray computed;
Angiography
- From:Chinese Journal of Medical Imaging Technology
2017;33(12):1811-1815
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between internal carotid artery (ICA) stenosis and ipsilateral retinal vascular calibers,and to investigate the feasibility and accuracy of changes of retinal vascular calibers for assessment of ICA stenosis.Methods Unilateral ICA and ipsilateral retinal vascular of 243 patients were enrolled based on CTA and fundus imaging.Patients were divided into 4 groups according to the highest ICA stenosis rate (Rmax),i.e.no stenosis group,mild stenosis group,moderate stenosis group and severe stenosis group.The differences of retinal vascular calibers among four groups and correlation between retinal vascular calibers and ICA stenosis were analyzed.Results The average central retinal vein equivalents (CRVE) in moderate ICA stenosis group and severe stenosis group were significantly wider than those in the other two groups (all P＜0.05).There was no statistical significance of central retinal artery equivalent (CRAE) nor retinal arteriolar-to-venular ratio (AVR) among groups (both P＞0.05).Rmax was positively correlated with CRVE (r=0.27,P＜0.01) and negatively correlated with AVR (r=-0.16,P＜0.05),whereas Rmax had no correlation with CRAE (P＞0.05).CRVE was the impact factor of ipsilateral Rmax (B=0.243,P＜0.01),but the adjusted R2 of the model was weak (0.173).Area under the ROC curve of CRVE was 0.619 in assessing ICA moderate and severe stenosis,and taking threshold as 229.5μm,the sensitivity and specificity was 80.3％ and 40.1％,respectively.Conclusion CRVE can assess and predict ICA stenosis to some extent,but the diagnosis efficacy is limited.
