The predictive value of AGEs in the risk and prognosis of coronary heart disease in diabetic patients
10.3760/cma.j.issn.1008-1372.2017.11.016
- VernacularTitle:AGEs对糖尿病患者发生冠心病风险及预后的预测价值
- Author:
Xiaosheng SHENG
1
;
Mingxing DING
;
Xian HUA
;
Zhangping YU
;
Xiaoxia YE
;
Fangming GUO
;
Beiwei YU
;
Wenwei XU
Author Information
1. 金华市人民医院心内科
- Keywords:
Diabetes mellitus,type 2/CO/ME;
Coronary disease/CO/ME;
Prognosis
- From:
Journal of Chinese Physician
2017;19(11):1665-1667,1671
- CountryChina
- Language:Chinese
-
Abstract:
Objective To predict the value of advanced glycation end products (AGEs) in the risk and severity of coronary heart disease in diabetic patients.Methods Totally 120 cases were divided into 3 groups.Group A had no diabetes mellitus (DM) and no coronary atherosclerotic heart disease (CAD).Group B had DM without CAD.Group C had DM with CAD.The levels of AGEs,low density lipoprotein cholesterol (LDL-C),glycosylated hemoglobin,and the severity of coronary stenosis were detected.Receiver operating characteristic (ROC) curve was used to evaluate the sensitivities and specificities of AGEs for the diagnosis of DM with CAD.Results The highest level of AGEs,LDL-C,glycosylated hemoglobin and carotid plaque was in the C group,with a statistically significant difference (P ＜ 0.05).The severity of AGEs was significantly correlated with the severity of CAD and the Gensini score of AGEs (r =0.445).ROC curve showed that the sensitivity,specificity and area under ROC curve of AGEs determination of DM with CAD were 80.0％,75.0％,and 0.86,respectivity.Conclusions The level of AGEs is significantly correlated with atherosclerosis and prognosis in DM.The severity of CAD was higher in the patients with higher AGEs,and the incidence and severity of restenosis increased.
