Relationship between blood levels of visfatin and glycolipid metabolism and mild cognitive impairment in patients with type 2 diabetes
10.3760/cma.j.issn.1008-1372.2017.11.019
- VernacularTitle:探讨Visfatin与糖脂代谢及2型糖尿病患者轻度认知障碍的相关性
- Author:
Yan MA
1
;
Lei WU
Author Information
1. 首都医科大学宣武医院综合科
- Keywords:
Nicotinamide phosphoribosyltransferase/ME;
Glycolipids/ME;
Diabetes mellitus,type 2/CO/ME;
Cognition disorders/CO/ME
- From:
Journal of Chinese Physician
2017;19(11):1676-1679
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between blood levels of visfatin and glycolipid metabolism and mild cognitive impairment (MCI) in patients with type 2 diabetes (T2DM).Methods From February 2016 to January 2017,a total of 91 patients with T2DM were recruited as investigation objects.Cognitive function was measured by Montreal Cognitive Assessment (MoCA),and fasting serum was collected to determine the relevant laboratory indexes.Results In the 91 patients,50 cases developed MCI.Compared to non-MCI group,MCI group had significant difference in age,total cholesterol,insulin,insulin resistance index,visfatin,MoCA score and diabetic retinopathy (P ＜ 0.05).Pearson correlation analysis showed that the MoCA score was negatively correlated with visfatin and insulin resistance index (P ＜0.05).Further logistic regression analysis showed that age,diabetic retinopathy,insulin resistance index and visfatin were independent risk factors for MCI in T2DM patients.Conclusions MCI in T2DM patients increases with the increasing of elder,diabetic retinopathy,insulin resistance index,and visfatin.
