Neutrophil/lymphocyte ratio in prediction of incidence of ischemic stroke in elderly persons with chronic kidney disease

VernacularTitle:中性粒细胞/淋巴细胞比值对老年慢性肾脏病患者发生缺血性脑卒中的预测价值
Author: Chen FU ¹ ; Lan YAO ; Shujun CHEN ; Jie YANG ; Haiping CHEN
Author Information

1. 100035,北京积水潭医院肾内科
Keywords: Neutrophils/ME; Lymphocytes/ME; Kidney diseases/CO/ME; Stroke/CO/ME
From: Journal of Chinese Physician 2017;19(11):1680-1683,1687
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship of the neutrophil to lymphocyte ratio (NLR)with stroke in elderly persons with CDK.Methods Totally 220 subjects with stage 3-5 CKD were followed.Fatal and nonfatal cerebrovascular event (CVE) were recorded during this period.NLR at baseline was determined from complete blood count differential.We investigated if NLR could predict stroke.Resuits Median NLR was 2.13.NLR was equally associated with estimated glomerular flitrationrate (eGFR).Totally 116 strokes occurred during follow-up period.NLR could predict stroke independently.Increased NLR over 2.13 was related to a significantly decreased survival time (log-rank Chi-square =4.963,P =0.026).Multivariate Cox regression analysis showed that the risk factor of ischemic stroke in CKD patients was high NLR,hazard ratio (HR) 1.11 [95％ confidence interval (CI) 1.007 to 1.223,P =0.035].Conclusions NLR could independently predict stroke in elderly patients with moderate to severe CKD.