Research progress on the mechanisms of chemotherapy resistance to glioblastoma in-duced by hypoxia microenvironment
10.3969/j.issn.1000-8179.2017.21.579
- VernacularTitle:缺氧微环境诱导胶质母细胞瘤耐药机制研究进展
- Author:
GAO YUGE
1
;
WANG HANBIN
;
ZHANG YAN
;
LI LI
Author Information
1. 哈尔滨医科大学附属第二医院肿瘤内科 哈尔滨市150001
- Keywords:
glioblastoma;
hypoxia;
microenvironment;
chemotherapy resistance
- From:
Chinese Journal of Clinical Oncology
2017;44(21):1100-1103
- CountryChina
- Language:Chinese
-
Abstract:
The chemotherapy resistance of glioblastoma is one of the main reasons leading to treatment failure. To date, many studies suggest that hypoxia microenvironment can induce resistance to chemotherapy and radiotherapy. Glioblastoma cells grow fast, and poor oxygen cannot supply enough nourishment. Thus, hypoxia microenvironment occurs. However, hypoxia can affect chemotherapy resistance of glioblastoma through different kinds of mechanisms. In this review, we by summarize the formation of hypoxic microenvi-ronment and the pathogenesis of glioblastoma chemotherapy resistance induced hypoxia.
