Relevance between the occurrence of chronic obstructive pulmonary disease and mitochondria DNA haplogroups
10.3969/j.issn.1001-6325.2017.12.013
- VernacularTitle:慢性阻塞性肺疾病发病与线粒体DNA单倍型相关
- Author:
Xiang ZHENG
1
;
Ying FENG
;
Li CHEN
;
cheng Zhi FANG
Author Information
1. 十堰市太和医院重症医学科
- Keywords:
chronic obstructive pulmonary disease;
genetic susceptibility;
mitochondria DNA;
haplogroup
- From:
Basic & Clinical Medicine
2017;37(12):1729-1732
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the relation between peripheral leukocytes mitochondria DNA(mtDNA) haplo-group and chromic obstructive pulmonary disease(COPD).Methods Sixty COPD patients and 45 healthy con-trols were recruited from Taihe Hospital .mtDNA hypervariable ( HVS ) region and 10171-10659 region were cloned and sequenced.Mutation sites were analyzed via aligning the target gene sequence with the rCRS ( revised Cambridge Reference Sequence) of mtDNA.Samples were divided into possible haplogroup according to mtDNA haplogroup classification tree of Han population.Results Both COPD group and control group were divided into 9 kinds of haplogroup, such as A, F and M7.A haplogroup has a higher proportion in COPD group than control group ( P<0.05) , while F haplogroup has a higher proportion in the control group than COPD group ( P<0.05) . Conclusions F haplogroup may reduce the COPD risk, while A haplogroup may be risk factor for COPD.The occurrence and development of COPD is potentially related to mtDNA haplogroup mutation .
