Study of characteristics of bone marrow hematopoietic recovery after accepting hematopoietic stem cell transplantation in patients with inv (9 ) blood system diseases
10.3969/j.issn.1673-4130.2017.22.020
- VernacularTitle:inv(9)血液病患者造血干细胞移植后骨髓造血恢复特征研究
- Author:
Hui ZHANG
1
;
Guohao GU
;
Lili WU
;
Jinlian PAN
Author Information
1. 苏州大学附属第一医院检验科
- Keywords:
inversion of chromosome 9;
blood system diseases;
fusion gene;
hematopoietic stem cell transplantation
- From:
International Journal of Laboratory Medicine
2017;38(22):3128-3130,3133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the characteristics of bone marrow hematopoietic recovery such as absolute neutrophil count (ANC) and platelet (PLT ) after accepting hematopoietic stem cell transplantation in the patients with inv (9) .Methods A total of 39589 cases of definitely diagnosed hematonosis in our hospital from January 2010 to October 2015 served as the research subjects . The R banding technique ,polymerase chain reaction(PCR) and flow cytometry instrument were adopted to check chromosome karyotype ,fusion gene and bone marrow hematopoietic recovery related indicators .Results PML-RARα,BCR-ABL1 ,AML-ETO , EVI1 ,CBFβ-MYH11 ,MLL-AF6 ,AML-AF4 ,SET-NUM214 ,SIL-TALI ,IgH rearrangement ,TCR rearrangement and BCL1-IgH and other fusion gene were detected in the patients with inv (9) hematonosis .The recovery situation after receiving hematopoietic stem cell transplantation in the patients with inv (9):ANC recovered to ＞0 .5 × 109/L on 12 d after transplantation ,PLT recovered to ＞20 × 109/L on 16 d after transplantation .The recovery situation after receiving hematopoietic stem cell transplantation in the patients with noninv(9):ANC recovered to ＞0 .5 × 109/L on 12 d after transplantation ,and PLT recovered to ＞20 × 109/L on 13 d after transplantation .Conclusion The time achieving ANC recovery ＞0 .5 × 109/L after hematopoietic stem cell transplantation in the patients with inv(9) and without inv(9) is almost similar ,while the time achieving PLT count recovery in the patients with inv(9) is slightly longer than that in the patients without inv(9) .
