Advances in antitumor functions and mechanisms of apolipoprotein A-Ⅰ
10.3969/j.issn.1000-8179.2017.20.750
- VernacularTitle:载脂蛋白A-Ⅰ的抗肿瘤作用及机制研究进展
- Author:
XIE LIYING
1
;
LUO XUEZHEN
;
CHEN XIAOJUN
Author Information
1. 复旦大学附属妇产科医院 上海市200011
- Keywords:
apolipoprotein A-Ⅰ (ApoA-Ⅰ);
tumor microenvironment;
therapeutic uses;
lipid metabolism;
ApoA-Ⅰ mimetics
- From:
Chinese Journal of Clinical Oncology
2017;44(20):1045-1048
- CountryChina
- Language:Chinese
-
Abstract:
Apolipoprotein A-Ⅰ (ApoA-Ⅰ), the predominant protein in plasma HDL, regulates cholesterol metabolism and exhibits anti-in-flammatory and antioxidant functions. Multiple clinical studies suggest that serum ApoA-Ⅰ levels are associated with the occurrence, development, and prognosis of malignant tumors. Laboratory research also shows that ApoA-Ⅰ and ApoA-Ⅰ mimetics exert antitumor ef-fects through antioxidation, immunoregulation, cholesterol metabolism, lysophosphatidic acid binding, and anti-angiogenesis. This pa-per reviews the role of ApoA-Ⅰ and ApoA-Ⅰ peptides in tumorigenesis and their potential value in diagnosis, treatment, and prognosis.
