Effect of rivaroxaban in the prevention of deep vein thrombosis after total hip replacement in elderly diabetic patients and its influence on plasma D-dimer level
10.3760/cma.j.issn.1008-6706.2017.24.024
- VernacularTitle:利伐沙班预防老年糖尿病患者全髋关节置换术后深静脉血栓形成的疗效及对血浆D-二聚体含量的影响
- Author:
Li LI
1
;
Hongqi YAN
;
Wei FANG
;
Zhigao LI
;
Bao ZHANG
Author Information
1. 合肥市第二人民医院关节骨科
- Keywords:
hip replacement;
diabetes mellitus;
Shaaban;
deep vein thrombosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(24):3768-3771
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of rivaroxaban in the treatment of deep vein thrombosis (DVT) after total hip replacement (THR) in elderly patients with diabetes mellitus and its influence on plasma D-dimer level.Methods 25 elderly patients with diabetes undergoing elective hip replacement (group B) and 25 elderly patients without diabetes mellitus (group A) were enrolled in this study.The two groups were orally given rivaroxaban for 2 weeks after operation.The results of color Doppler diagnosis of DVT were compared between the two groups,and the content of D-dimer in plasma was detected.Results Before and after operation,the INR between the two groups had no statistically significant differences (P ＞ 0.05).The D-dimer levels of the two groups before operation were obviously.lower than those postoperative 2 and 7 days (t =3.145,P ＜ 0.05).Preoperative D-dimer value was slightly lower than those postoperative 14 days (P ＞ 0.05),the value of postoperative 2 days was significantly higher than those postoperative 7 and 14 days (t =3.763,P ＜ 0.05),the value of postoperative 7 days was significantly higher than those postoperative 14 days (t =2.876,P ＜0.05).There was no DVT in thetwo groups of A and B,and no severe bleeding occurred in the two groups.Conclusion Rivaroxaban in the treatment of elderly diabetic patients with THR surgery,can effectively reduce the formation of lower extremity DVT.At the same time,through detection of plasma D-dimer content can accurately judge the occurrence of DVT,which has guiding significance for prevention and treatment of DVT.
