Predictive Value of Lipoprotein-associated Phospholipase A2 in Patients With Acute Coronary Syndrome
10.3969/j.issn.1000-3614.2017.12.007
- VernacularTitle:急性冠状动脉综合征患者脂蛋白相关磷脂酶A2的预测价值
- Author:
ni Xing MIAO
1
;
lu De YIN
;
hua Xin ZHAO
;
Yu CHEN
;
Yi ZHOU
;
Ying WANG
;
Ping DUAN
;
xing Qun LI
Author Information
1. 连云港市第一人民医院 心内科
- Keywords:
Acute coronary syndrome;
Phospholipases;
GRACE score
- From:
Chinese Circulation Journal
2017;32(12):1172-1176
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the risk predictive value of lipoprotein-associated phospholipase A2 (Lp-PLA2) on acute coronary syndrome(ACS) and to study the relationship between Lp-PLA2 and the severity of coronary stenosis in ACS patients. Methods:A total of 155 ACS patients admitted in our hospital were enrolled. The patient were divided into 2 groups:AMI (acute myocardial infarction) group, n=49 and UA (unstable angina)group, n=106; in addition, there was a Control group, n=44 subjects with normal coronary angiography (CAG).Blood levels of Lp-PLA2 were examined, CAG was conducted and GRACE score, SYNTAX score,Gensini score were calculated. Based on Grace score, ACS patients were divided into 3 subgroups: Low risk subgroup, Grace score≤108, Mid risk subgroup,Grace score 109-140 and High risk subgroup,Grace score≥140.The above parameters were comparedamong different groups. Results: Compared with UA group and Control group, AMI group had increased blood level of Lp-PLA2, P<0.05. Compared with Low risk subgroup, High risk subgroup had much higher Lp-PLA2, P<0.05. Correlation analysis showed that Lp-PLA2 level was positively related to Gracescore (r=0.301, P<0.001). By SYNTAX score and Gensini score evaluation,Lp-PLA2 levels were similar among different subgroups. Conclusion:Blood level of Lp-PLA2 had certain risk predictive value in ACS patients; while it was not related to the severity of coronary stenosis.
