Progress on role of exosomes derived from leukemia cells

VernacularTitle:白血病细胞源外泌体的作用研究进展
Author: juan Juan ZHANG ¹ ; wei Rui LI ; gang Ji HE ; mei Hong OUYANG ; lian Ya SA
Author Information

1. 昆明理工大学附属医院
Keywords: Leukemia cells; Exosomes; Biological functions; Molecular mechanism
From: Chinese Journal of Pathophysiology 2017;33(12):2287-2292
CountryChina
Language:Chinese
Abstract: Exosomes are bilayer-lipid membrane nanovesicle from almost all living cell types which are in-volved in intercellular substance transporting and signaling communication .Exosomes are 30 ~120 nm in diameter , can transfer bioactive molecules including DNA , RNA, microRNA, protein as well as lipids derived from parents ' cells to re-cipient cells by body fluids , and specifically influence their physiological or pathological conditions .Leukemia is due to malignant proliferation of hematopoietic stem and progenitor cells .It was reported that leukemia cells derived exosomes play a key role in disease progression , drug resistance , and predict prognosis .This paper will outline the role of exosomes de-rived from leukemia cells and provide important information to help explore the molecular pathogenesis , biomarker as well as therapeutic target of leukemia .