Progress in function of HDL-eNOS signaling pathway in cardiovascular system and it' s influencing factors
10.3969/j.issn.1000-4718.2017.12.030
- VernacularTitle:高密度脂蛋白-内皮型一氧化氮合酶信号通路在心血管系统中的作用及其影响因素的研究进展
- Author:
li Xin ZHANG
1
;
Min WANG
;
hua Guang LUO
;
ying Xiao ZHANG
Author Information
1. 苏州大学附属第三医院 心胸外科
- Keywords:
High-density lipoprotein;
Apolipoprotein;
Sphingosine 1-phosphase;
Endothelial nitric oxide synthase;
Paraoxonase 1
- From:
Chinese Journal of Pathophysiology
2017;33(12):2293-2298
- CountryChina
- Language:Chinese
-
Abstract:
High-density lipoprotein ( HDL) is negatively related to the risk of cardiovascular diseases such as atherosclerosis .Recent studies have shown that HDL activates a variety of target cells , such as vascular endothelial cells and macrophages , and activates the related cell signaling pathway to exert an anti-atherosclerosis role .HDL is a complex substance which composes of multiple particles .The changes of many factors affect the characteristics and functions of HDL, and then affect the activation of endothelial nitric oxide synthase ( eNOS) .This paper summarizes the recent correla-tion studies, and expounds the related factors that affect the HDL-eNOS signaling pathway .
