Advances on studies of miR-21 in vascular endothelial function and angiogenesis
10.3969/j.issn.1000-4718.2017.12.031
- VernacularTitle:miR-21对血管内皮功能及血管生成 调节作用的研究进展
- Author:
yong Xiao TAN
1
;
Dan FANG
;
bo Jian WU
;
Mao LUO
Author Information
1. 西南医科大学药物研究中心
- Keywords:
MicroRNA-21;
Vascular endothelial cells;
Angiogenesis;
Cardiovascular disease
- From:
Chinese Journal of Pathophysiology
2017;33(12):2299-2304
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs ( miRNAs) are a class of non-coding , endogenous , single-stranded small RNA mole-cules composed of 19~25 nucleotides .miRNAs are widely involved in the process of human life activities .Recent studies have shown that part of miRNAs regulate the vascular endothelial function and angiogenesis .High expression of miRNA-21 is found to play important roles in the cell proliferation , cell apoptosis , cell growth and death of vascular endothelial cells . This review will focus on the recent progress related to miRNAs in vascular endothelial function and angiogenesis , providing a new insight in cardiovascular disease prevention , clinical diagnosis , prognosis and target therapeutics .
