A pilot study of lung ultrasound B-lines in diagnosis of rheumatoid arthritis associated interstitial lung diseases
10.3760/cma.j.issn.1007-7480.2017.11.004
- VernacularTitle:肺超声B线诊断类风湿关节炎相关间质性肺疾病的初步研究
- Author:
Yukai WANG
1
;
Guangzhou DU
;
Zhangzhang LIN
;
Shaoqi CHEN
;
Qisheng LIN
;
Yaobin WU
;
Chanjun LIN
;
Chuling WU
Author Information
1. 515031,广东省汕头市中心医院风湿免疫科
- Keywords:
Arthritis,rheumatoid;
Interstitial lung disease;
Lung ultrasound;
B-lines;
High resolution CT
- From:
Chinese Journal of Rheumatology
2017;21(11):738-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the clinical value of lung ultrasound (LUS) B-lines in diagnosis of rheumatoid arthritis (RA) associated interstitial lung diseases (RA-ILD).Methods Forty-five consecutive patients with RA who underwent a high resolution computed tomography (HRCT) scan of the chest,were also examined by LUS for detection of B-lines(within 1 month independently in all patients).The B-lines score was obtained by summing the number of total 50 inter-costal spaces (ICSs) of chest wall.Pulmonary fibrosis was quantified by HRCT as previously described by the 30-point Warrick score.Results B-lines score significantly correlated with the Warrick score [(r=0.778,95％CI(0.627,0.872),P＜0.05].Receiver operating characteristic (ROC) curve confirmed that B-lines cut-off point 77[sensitivity of 100％,specificity of 64.3％ respectively,area under curve [AUC] =0.86,95％CI(0.724,0.945)] and 108[sensitivity of 90％,specificity of 88.6％ respectively,AUC=0.879,95％CI(0.747,0.957)] had an optimal power to discriminate mild (Warrick score＜8) and severe fibrosis (Warrick score＞15):Conclusion The data confirm that LUS is a useful technique to identify ILD in RA.In RA-ILD,B-lines correlate significantly with HRCT and are able to identify mild and severe degree of fibrosis.LUS is a promising non-invasive and non-ionizing strategy for screening RA-ILD.
