Andersson lesion in ankylosing spondylitis: a systematic review
10.3760/cma.j.issn.1007-7480.2017.11.008
- VernacularTitle:强直性脊柱炎合并Andersson损害的系统评价
- Author:
Yang LIU
1
;
Hongyan WEN
;
Xiaofeng LI
Author Information
1. 山西医科大学第二医院风湿免疫科
- Keywords:
Spondylitis,ankylosing;
Andersson lesion;
Systematic review
- From:
Chinese Journal of Rheumatology
2017;21(11):759-762
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features of Andersson lesion (AL) in ankylosing spondylitis (AS).Methods A comprehensive search was performed for all scientific literatures using search string "ankylosing spondylitis Andersson lesion vertebral lesion destructive lesion spondylodiscitis" "discitis" "pseudarthrosis" or "stress fracture" published between January 1937 and December 2016.Literature screening and data extraction were done according to the inclusion and exclusion criteria.Statistical Product and Service Solutions (SPSS) 23.0 software was used for statistical analysis.Data was analyzed by one sample t test and paired sample t test.Results Fifteen papers were selected after literature review (57) and 47 cases met the selection criteria fimally.Male patients was 38(81％) and female was 9(19％),and their average age was (45±12) years old.The disease duration was defined as the time range from the definite diagnosis of AS to the onset of AL and it was between 0.5 to 41years with the average of (11±7) years.Twenty-four cases (51％) had a clear history of trau.ma.Twenty cases (43％) performed kyphosis in which thoracolumbar segments (15 cases)was the most commonly involvedand the difference was statistically significant (P＜0.05).Four cases (9％) were misdiagnosed as tuberculosis.There was no statistically different for preoperative and postoperative ESR and CRP (P＞0.05).The above cases were confirmed by imageology (42 cases) and magnetic resonance imaging (MRI) was the best method.Forrty cases (85％) were treated by surgery and the other 7 cases (15％) were treated with immunosuppressive therapy.Conclusion AS patients with AL are always associated with trauma and diagnosed by means of MRI.Orthopedic effect and good fusion can be obtained by pedicle and intervertebral disc osteotomy which is an effective method for the treatment of AS with AL.
