Subcutaneous panniculitis-like T-cell lymphoma: report of five cases and review of literature
10.3760/cma.j.issn.1009-9921.2017.10.006
- VernacularTitle:皮下脂膜炎样T细胞淋巴瘤五例并文献复习
- Author:
Qian SUN
1
;
Cheng XU
;
Chongyang DING
;
Li WANG
;
Lei FAN
;
Wei XU
;
Jianyong LI
Author Information
1. 210029,南京医科大学第一附属医院 江苏省人民医院血液科
- Keywords:
Panniculitis;
Lymphoma;
T-cell;
Pathology;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2017;26(10):605-610
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the clinical characteristics and prognosis of subcutaneous panniculitis-like T-cell lymphoma(SPTCL). Methods This study retrospectively analyzed the clinical data of 5 SPTCL patients diagnosed in the First Affiliated Hospital with Nanjing Medical University, and presented with a corresponding literature review. Results Four patients initiated symptoms with rash. Three patients had hepatomegaly and/or splenomegaly, and one was accompanied with hemophagocytic lymphohistiocytosis (HLH). Tumor cells diffusely infiltrated into subcutaneous tissues with hemotoxylin and eosin staining, and rimmed around single adipocyte. The neoplastic cells consistently expressed proteins of CD3, CD43 and CD45RO, and characteristically had the phenotype of CD4- CD8+CD56- T cells which expressed cytotoxic proteins. Two of five patients received DHAP courses as initial treatment, and three patients took the DA-EPOCH recipe. Two patients received autologous stem cell transplantation as second-line treatment. Median overall survival(OS)time was not reached(range 4-107 months), and five-year survival rate was 75 %. While the OS time of patient with HLH was only 10 months. Conclusion Patients with SPTCL own a relatively good prognosis,but those accompanied with HLH have poor outcome.
