Motivation of Chinese patients with chronic myelogenous leukemia who have stopped the tyrosine kinase inhibitor
10.3760/cma.j.issn.1009-9921.2017.10.007
- VernacularTitle:慢性粒细胞白血病患者酪氨酸激酶抑制剂停药原因分析
- Author:
Qing LI
1
;
Hui CHENG
;
Yong YOU
;
Zhaodong ZHONG
;
Weiming LI
;
Li MENG
;
Xiaojian ZHU
;
Ping ZOU
Author Information
1. 430022,武汉市第一医院血液内科
- Keywords:
Leukemia;
myelogenous;
chronic;
Treatment-free remission;
Withdrawal
- From:
Journal of Leukemia & Lymphoma
2017;26(10):611-613
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the motivation of Chinese patients with chronic myelogenous leukemia (CML) who have stopped the tyrosine kinase inhibitor (TKI). Methods Forty-seven CML patients who have stopped TKI provided informed consent prior to their participation in the study. These patients were divided into relapse and non-relapse group at the endpoint of the observation. None of the patients received any CML-associated therapies after TKI cessation. The reasons of withdrawal were analyzed statistically. Results The reasons for cessation included patient's request due to cost(59.57 %, 28/47), patient's plan to getting pregnant(8.52 %,4/47),side-effect of TKI(23.40 %,11/47)and other reasons(8.52 %,4/47).At the endpoint of observation, 23 patients suffered molecular relapse. Among them, 15 cases (65.22 %) were due to cost; 1 case (4.35 %) was due to getting pregnant, 5 cases (21.74 %) were due to side-effect and 2 cases (8.69 %) were due to other reasons. There was more frequency relapse in the group of insufficient cost. Conclusion The motivation of Chinese CML patients who have stopped TKI might show impact on the outcome,and the motivation is mainly related with history of drug reduction and withdrawal.
