Research progress on superparamagnetic iron oxide nanoparticles for targeted drug delivery
10.3760/cma.j.issn.1673-4181.2017.04.012
- VernacularTitle:超顺磁性氧化铁纳米颗粒在药物靶向递送中的研究进展
- Author:
Ruoyu ZHAO
1
;
Yuntao LI
;
Xiang LU
Author Information
1. 210011,南京医科大学第二附属医院全科医学科
- Keywords:
SPIONs;
Target therapies;
Nanodrug carriers;
Toxicity
- From:
International Journal of Biomedical Engineering
2017;40(4):286-290
- CountryChina
- Language:Chinese
-
Abstract:
Superparamagnetic iron oxide (SPIO) is a novel biomedical nanomaterial with surface effect,small size effect and macroscopic quantum tunneling effect.It has good biocompatibility and superparamagnetism which makes it widely used in targeted therapies.Compared to other nanodrug carriers,superparamagnetic iron oxide nanoparticles (SPIONs) have great potentials in nanodrug filed due to their properties such as intrinsic magnetic,good safety and the availability of surface modifications,etc.These properties provide the basis for their diverse applications in biomedical field.However,researchers are still concerned about the unpredictable toxicity and the changes in cell signal transduction and gene expression of SPIONs.In this paper,the research progress of SPIONs for drug targeting delivery was summarized.
