Research progress of the cell microencapsulation
10.3760/cma.j.issn.1673-4181.2017.04.013
- VernacularTitle:细胞微囊化技术的研究进展
- Author:
Huajiang DONG
1
;
Gang LI
;
Shaohui WANG
;
Yue YANG
;
Huijuan YIN
;
Xiaohong LI
;
Mingliang ZHAO
;
Ling LIN
Author Information
1. 精密测试技术及仪器国家重点实验室
- Keywords:
Cell microencapsulation;
Immune isolation;
Cytokines;
Organ transplantation
- From:
International Journal of Biomedical Engineering
2017;40(4):291-294,301
- CountryChina
- Language:Chinese
-
Abstract:
Cell microencapsulation aims to wrap the living target cells by one or several materials with good biological compatibility and semipermeable membrane properties.Cell microencapsulation not only can achieve immune isolation and prevent the attacks by macromolecular immunes and immune cells,but also can allow the free access of metabolites,small molecule nutrients and bioactive substances to the microcapsule.With the continuous progress of interdisciplinary technologies,cell microencapsulation shows increasing application prospects of making up a variety of limitations of organ transplantation.Moreover,with the development and maturation of cell microencapsulation,it has shown a strong advantage in regenerative medicine,which will certainly promote the rapid development of artificial cells and artificial organs.In this paper,the preparation of cell microcapsules,the effects of the outer membrane of microcapsules on immunological macromolecules and cytokines,the immunogenicity of the outer membrane,and the representative applications of cell microencapsulation were summarized.
