Anti-fatigue effect of arginyl fructosyl glucose from red ginseng in mice
10.13481/j.1671-587x.20170508
- VernacularTitle:红参中精氨酸双糖苷对小鼠的抗疲劳作用
- Author:
Baoliang HUANG
1
;
Chuanbo DING
;
Jiaqi WANG
;
Yinan ZHENG
;
Wencong LIU
;
Jing ZHANG
;
Xiaohua XU
Author Information
1. 吉林农业大学中药材学院中药化学室
- Keywords:
red ginseng;
arginyl fructosyl glucose;
exhaustive swimming training;
real-time fluorescence quantitative polymerase chain reaction;
Western blotting method
- From:
Journal of Jilin University(Medicine Edition)
2017;43(5):897-902
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the anti-fatigue phenomenon induced by forced swimming in the mice,and to explore the anti-fatigue effect of argininyl fructoyl glucose (AFG) from red ginseng in the mice and its mechanism.Methods:The AFG was extracted from red ginseng.The ICR mice were divided into blank control group,low dose of AFG group (100 mg · kg-1),middle dose of AFG group (200 mg · kg-1) and high dose of AFG group (400 mg · kg-1) (n=20).The mice mere given a forced swimming test after continuous gavage for 28 d.The weights,organ indexes,time of forced swimming,contents of lactic acid (LD),blood urea nitrogen (BUN),hepatic glycogen (Gly) and expressing levels of PGC-1α in gastrocnemius of the mice in various groups were detected.Results:Compared with blank control group,the weights and organ indexes of the mice in low,middle and high doses of AFG groups had no significant differences (P＞ 0.05).Compared with blank control group,the time of forced swimming,contents of Gly and expressing levels of PGC-1α of the mice in low,middle and high doses of AFG groups were significantly increased (P＜0.05 or P＜0.01) in a dose-dependent manner.Compared with blank control group,The contents of LD and BUN in serum of the mice in low,middle and high doses of AFG groups were significantly decreased (P＜0.01).Conclusion:AFG has anti-fatigue effect in mice,and its mechanism may be related to energy metabolism.
