Analysis of Therapeutic Efficacy of Benazepril Combined with Metoprolol in the Treatment of Elderly Essential Hypertension Complicated with Heart Failure
10.6039/j.issn.1001-0408.2017.27.12
- VernacularTitle:贝那普利联合美托洛尔治疗老年原发性高血压伴心力衰竭的疗效分析
- Author:
Hua PAN
1
;
Jianrong YIN
Author Information
1. 邳州市人民医院药剂科
- Keywords:
Elderly;
Essential hypertension;
Heart failure;
Benazepril;
Metoprolol;
Therapeutic efficacy;
Safety
- From:
China Pharmacy
2017;28(27):3788-3790
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe therapeutic efficacy and safety of benazepril combined with metoprolol in the treatment of elderly essential hypertension complicated with heart failure.METHODS:In retrospective analysis,100 elderly patients with essential hypertension complicated with heart failure were divided into control group (50 cases) and observation group (50 cases) according to drug plan.Based on routine treatment,control group was given Benazepril hydrochloride tablet 10 mg orally,once a day.Observation group was additionally given Metoprolol tartmte tablet with initial dose of 6.25 mg,twice a day,then increased 50-100 mg based on the improvement,twice a day,on the basis of control group.Relevant indicators were observed after 6 months of treatment.Clinical efficacies as well as SBP,DBP,brachial-ankle pulse wave velocity (baPWV),resting heart rate,LVEF,SV and the occurrence of ADR before and after treatment were observed in 2 groups.RESULTS:Total response rate of observation group (88.0％) was significantly higher than that of control group (62.0％),with statistical significance (P＜0.05).Before treatment,there was no statistical significance in SBP,DBP,baPWV,resting heart rate,LVEF and SV between 2 groups (P＞0.05).After treatment,SBP,DBP and baPWV of 2 groups were significantly lower than before,and the observation group was significantly lower than the control group;LVEF and SV of 2 groups were significantly higher than before,and the observation group was significantly higher than the control group;resting heart rate of observation group was significantly lower than before and that of control group,with statistical significance (P＜0.05),but there was no statistical significance in resting heart rate of control group before and after treatment (P＞0.05).No significant ADR was found in 2 groups during treatment.CONCLUSIONS:Based on routine treatment,benazepril combined with metoprolol show significant therapeutic efficacy for elderly hypertension complicated with heart rate,can improve cardiac function and blood pressure with good safety.
