Meta-analysis of Haikun Shenxi Capsule in the Treatment of Chronic Renal Failure
10.6039/j.issn.1001-0408.2017.27.17
- VernacularTitle:海昆肾喜胶囊治疗慢性肾功能衰竭的Meta分析
- Author:
Meifang LIU
1
;
Jiasheng HUANG
;
Jiawei HE
;
Qiaoli HUA
;
Lei ZHANG
;
Xusheng LIU
Author Information
1. 广东省中医院
- Keywords:
Haikun shenxi capsule;
Chronic renal failure;
Meta-analysis;
System review;
Therapeutic efficacy
- From:
China Pharmacy
2017;28(27):3801-3804
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review therapeutic efficacy of Haikun shenxi capsule in the treatment of chronic renal failure (CRF).METHODS:Retrieved from Central,PubMed,EMBase,CJFD,CBM,VIP and Wanfang database,randomized clinical trials (RCTs) about Haikun shenxi capsule combined with routine treatment (trial group)vs.single routine treatment (control group) in the treatment of CRF were collected.Meta-analysis was performed by Rev Man 5.3 software after screening literature,extracting data and evaluating quality by using risk bias evaluation of Cochrane collaboration network.RESULTS:A total of 10 RCTs were included eventually,involving 704 patients.The results of analysis showed that compared to general therapy,Haikun shenxi capsule could improve total effective rate [RR =4.42,95 ％ CI (2.70,7.22),P＜ 0.001],and could reduce SCr[MD =-140.37,95 ％ CI (-191.72,-89.03),P＜ 0.001],BUN[MD =-5.49,95 ％ CI (-8.36,-2.63),P＜ 0.001] and 24 h-Upro [MD =-0.43,95 ％ CI (-0.62,-0.23),P＜ 0.001],with statistical significance.CONCLUSIONS:The clinical efficacy of Haikun shenxi capsule in the treatment of CRF is good and significantly improve related indexes of renal function.
