Effects of Compound Danshen Dripping Pills or Tablets on Chronic Hepatitis B Complicated with Hepatic Fibrosis: A Systematic Review
10.6039/j.issn.1001-0408.2017.27.20
- VernacularTitle:复方丹参滴丸/片对慢性乙型肝炎肝纤维化作用的系统评价
- Author:
Fuyong ZHANG
1
;
Bin YU
;
Kun CHEN
;
Shurong WANG
Author Information
1. 西南医科大学药学院
- Keywords:
Compound danshen dripping pills;
Compound danshen tablets;
Chronic hepatitis B;
Liver fibrosis;
Systematic review;
Therapeutic efficacy
- From:
China Pharmacy
2017;28(27):3817-3820
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the efficacy of Compound danshen dripping pill or Compound danshen tablets for chronic hepatitis B complicated with hepatic fibrosis,and to provide evidence-based reference for clinical treatment.METHODS:Retrieved from PubMed,Cochrane Library,EMBase,Medline,Wanfang database,VIP,CJFD and CBM database,randomized controlled trials (RCTs) about Compound danshen dripping pills or tablets combined with entecavir(trial group) vs.entecavir alone (control group) for chronic hepatitis B complicated with hepatic fibrosis were collected.Meta-analysis was performed by using Rev Man 5.3 statistical software after data extraction and quality evaluation according to Cochrane systematic evaluation manual 5.1.0.RESULTS:A total of 9 RCTs were enrolled,including 714 patients.The results of Meta-analysis showed that ALT [SMD=-0.44,95％CI(-0.86,-0.01),P=0.04],HA [SMD=-1.53,95％CI(-2.28,-0.79),P＜0.001],LN [SMD=-0.93,95％CI(-1.41,-0.46),P＜0.001],CⅣ [SMD=-1.38,95％CI(-2.13,-0.63),P＜0.001] and PCⅢ [SMD=-1.42,95％ CI (-1.60,-1.23),P＜0.001] of trial group were significantly lower than those of control group;HBV-DNA negative rate [OR=3.73,95 ％ CI (2.14,6.49),P ＜ 0.001] was significantly higher than control group,with statistical significance.CONCLUSIONS:Compound danshen dripping pills or tablets can not only improve liver function and liver fibrosis in chronic hepatitis B patients with hepatic fibrosis,but also improve the antiviral effect.
