Comparison of Therapeutic Efficacy and Safety between Chlorquinaldol-promestriene and Miconazole Nitrate for Simple Vulvovaginal Candidiasis
10.6039/j.issn.1001-0408.2017.27.13
- VernacularTitle:氯喹那多-普罗雌烯与硝酸咪康唑治疗单纯性外阴阴道假丝酵母菌病的疗效与安全性比较
- Author:
Ying DU
1
;
Chunquan ZHAO
;
Yulin ZHANG
;
Yang LIU
Author Information
1. 重庆医科大学附属第一医院,重庆400016
- Keywords:
Simple vulvovaginal candidiasis;
Chlorquinaldol-promestriene;
Miconazole nitrate;
Therapeutic efficacy;
Safety
- From:
China Pharmacy
2017;28(27):3791-3793
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare therapeutic efficacy and safety of chlorquinaldol-promestriene and miconazole nitrate for simple vulvovaginal candidiasis (VCC).METHODS:In retrospective analysis,a total of 231 patients with simple VCC were divided into observation group (116 cases) and control group (115 cases).Observation group was given Chlorquinaldol-promestriene vaginal tablet (0.2 g) every night.Control group was given Miconazole nitrate suppositories (200 mg) every night.Both groups received a course of treatment,lasting for 7 d.Clinical efficacies of 2 groups were observed at the first and second recheck.The symptom relief time recurrence and ADR of effective patients were observed.RESULTS:There was no statistical significance in the total response rates of 2 groups at the first reexamination,as well as total response rates of 2 groups and symptom relief time of effective patients at the second reexamination(P＞0.05).At the second reexamination,reoccurrence rate of observation group was significantly lower than that of control group,with statistical significance (P＜0.05).There was no statistical significance in the incidence of ADR between 2 groups(P＞0.05).CONCLUSIONS:Chlorquinaldol-promestriene is similar to miconazole nitrate for VCC in therapeutic efficacy and safety,but chlorquinaldol-promestriene is better than miconazole nitrate in reducing recurrence rate.
