Research updates on surgical treatments for portal hvpertension
10.3760/cma.j.issn.1007-8118.2017.09.017
- VernacularTitle:门静脉高压症外科治疗进展
- Author:
Jinwei YANG
1
;
Zhen MA
;
Jike HU
;
Tianliang SONG
;
Xiaohong LIU
;
Chunyu GENG
;
Zhijian HAN
;
Yumin LI
;
Hao CHEN
Author Information
1. 730030,兰州大学第二临床医学院
- Keywords:
Portal hypertension;
Surgical treatment;
Shunt;
Disconnection;
Transjugular intrahepatic portosystemic shunt (TIPS);
Liver transplantation
- From:
Chinese Journal of Hepatobiliary Surgery
2017;23(9):640-645
- CountryChina
- Language:Chinese
-
Abstract:
Portal hypertension is a common clinical syndrome in chronic liver disease,such as schistosomiasis,portal vein occlusion cirrhosis and so on,which can be diagnosed when the hepatic venous pressure gradient is (HVPG) ＞ 5 mmHg (1 mmHg =0.133 kPa).It could lead to gastroesophageal varicose veins rupture,ascites,spontaneous bacterial peritonitis,hepatorenal syndrome,hepatopulmonary syndrome,hepatic encephalopathy and some other serious complications,and is the primary death cause in cirrhosis and liver transplantation.The development of portal hypertension has experienced 4 phases ineluding the research about portal hypertension related theories and animal trial phase,preclinical tests and data accumulation phase,devascularization and shunts rapid development phase,the development phase of new technologies such as interventional and endoscopic surgical treatment,liver transplantation since the middle of the 19th century.The surgical procedures have been modified,which greatly reduce the complication and improve the life quality after operation.But so far none of them can cure portal hypertension thoroughly.This paper not only introduces the pathophysiologic basis of the surgical treatment,but also reviews the history of its development to summarize the recent progress,which may facilitate its surgical treatment.
