Repairing peripheral nerve injury with nerve conduits
10.3969/j.issn.2095-4344.2017.30.024
- VernacularTitle:神经导管支架修复外周神经损伤的研究与现状
- Author:
Yong CHEN
1
;
Lin FAN
;
Zhen FU
;
Yan XIONG
;
feng Yan WANG
;
fa Qi YE
;
Wei QIN
Author Information
1. 武汉大学中南医院
- From:
Chinese Journal of Tissue Engineering Research
2017;21(30):4901-4907
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: In recent years, the rapid development of medical and tissue engineering has provided more choices for making nerve conduit preparation. OBJECTIVE: To review the application of nerve conduits in the repair of peripheral nerve injury. METHODS: The first author retrieved the CNKI and PubMed databases to search relevant articles published from 2010 to 2016. The key words were "nerve conduit, peripheral nerve" in Chinese and English, respectively.RESULTS AND CONCLUSION: The nerve conduit materials are mainly classified into biotype and non-biotype. Biotype materials mainly include muscle, amniotic membrane, vein and small intestinal submucosal layer. The non-biotype materials include chitosan, collagen, silk fibroin, polylactic acid, polycaprolactone, polyaniline and silicone tubes. Some materials currently have been approved to enter the clinical stage. There are more or less problems in the clinical application of nerve conduits in the repair of peripheral nerve injury. For example, the length of a defect that can be repaired is limited; the mechanical properties and mechanical properties are not exactly matched with nerve regeneration; the degradation rate is inconsistent with the rate of nerve regeneration; and poor biocompatibility exists.
