Mechanism and application of autologous platelet-rich plasma in the treatment of joint and sports injuries
10.3969/j.issn.2095-4344.2017.30.025
- VernacularTitle:自体富血小板血浆治疗骨关节与运动损伤疾病的机制与应用
- Author:
xin Jia FU
1
;
sen Shu WANG
Author Information
1. 天津市第三中心医院骨科
- From:
Chinese Journal of Tissue Engineering Research
2017;21(30):4908-4914
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Platelet-rich plasma is an autologous plasma product that is simple and easy to be obtained, and has been widely used in a variety of sports injuries, non-infectious tendon and ligament injuries, nonunion, bone healing, and cartilage repair, because it contains a large number of growth factors that promote tissue healing and soft tissue regeneration. However, its actual effects are uncertain.OBJECTIVE: To introduce the pathophysiological mechanism, preparation and preservation of autologous platelet-rich plasma and to review the research status of autologous platelet-rich plasma in the treatment of bone and joint injuries induced by sports.METHODS: A computer retrieval in WanFang, CNKI, and PubMed databases was performed for articles addressing clinical and laboratory reports on autologous platelet-rich plasma for diseases of bone and joint injuries published from 1990 to 2016. Then, we summarized the research status of autologous platelet-rich plasma in the treatment of bone and joint diseases and motor system damage.RESULTS AND CONCLUSION: The mechanism of autologous platelet-rich plasma to repair bone and soft tissue injuries is not yet fully understood, and there is still a lot of reasoning and speculation. Moreover, its dose, treatment course, administration route and method of use have not been fully standardized, and there are still no clear guidelines for its clinical use. Autologous platelet -rich plasma has a broad application prospect in the treatment of bone and joint injuries, but it is still in the initial exploratory stage, which needs further observation and summarization to get more powerful evidence. Up to now, there are few samples in the world, in the absence of effective control standards, and long-term large-sample rigorous research is required to reach the final conclusion.
