Advance of improving the survival rate of transplanted cells in myocardial infarction area
10.3760/cma.j.issn.1001-4497.2017.09.018
- VernacularTitle:提高移植细胞在心肌梗死区域存活率的研究进展
- Author:
Feng ZHU
1
;
Guoxing WENG
Author Information
1. 福建省立医院心外二科
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2017;33(9):573-576
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction and other cardiovascular diseases are one of the main causes of human death.Myocardial infarction leads to a reduction in the number of regional myocardial cells,cardiac decompensation,myocardial fibrosis,and heart failure.At present,the main treatment methods of myocardial infarction include drug therapy,coronary stent implantation,coronary artery bypass grafting and heart transplantation.However,these methods have limitations.In particular,irreversible heart failure cause by myocardial fibrosis and ventricular remodeling is difficult to treat.Cell transplantation therapy can repair necrotic myocardium,which may provide a potential for myocardial regeneration.However,the survival rate of transplanted cells is low,which affects the effect of transplantation.The review focuses on the development of cell transplantation therapy in recent years and the factors that improve the survival rate of transplanted cells.
