Early experience of lung transplantation using graft lungs from donation after citizens death
10.3760/cma.j.issn.0254-1785.2017.08.002
- VernacularTitle:20例肺移植的早期临床经验总结
- Author:
Xin XU
1
;
Guilin PENG
;
Bing WEI
;
Chunrong JU
;
Dong XIAO
;
Minzhang GUO
;
Zhexue HAO
;
Wei WANG
;
Weiqiang YIN
Author Information
1. 510120,广州医科大学附属第一医院 广州呼吸疾病研究所
- Keywords:
Lung transplantation;
Organ procurement organization;
Lung protection
- From:
Chinese Journal of Organ Transplantation
2017;38(8):455-458
- CountryChina
- Language:Chinese
-
Abstract:
Objective To report the results of lung transplantation using graft lungs from donation after citizens death.Methods The clinical data of lung transplantation between January 2016 and June 2016 were analyzed retrospectively.Results Totally 20 patients with end stage lung diseases underwent lung transplantation.Of the 20 patients,11 cases (55％) underwent single lung transplantation and 9 cases (45 ％) underwent bilateral lung transplantation.The top two diseases for lung transplantation were pulmonary fibrosis in 11 cases (55％) and emphysema in 6 cases (30％).Four cases (20％) were given intraoperative ECMO support.Median duration of postoperative intubation was 2 days:1 day for single lung transplantation and 4 days for bilateral lung transplantation,respectively.Acute rejections were diagnosed in 9 patients (45％) who were successfully treated with high-dose intravenous methylprednisolone or methylprednisolone combined with anti-human thymocyte globulin.Postoperative pneumonia episodes occurred in 16 cases (80％)and 4 of them were associated fungal pneumonia.Preoperative sputum culture showed positive bacteria in 16 donors (80％) and 17 kinds of strains were identified.Postoperative sputum culture showed positive bacteria in 19 recipients and 4 of them had the same strains as compared with the corresponding donors.One recipient died of primary graft dysfunction in early term (＜ 1 month)postoperatively,two recipients abandoned treatments and died in 1 week after the discharge,and the remaining 17 cases successfully recovered.Median hospital duration was 55 days:35 days for single lung transplantation and 67 days for bilateral lung transplantation,respectively.Conclusion LLung transplantation is an effective treatment for end-stage lung diseases.Carefully selecting donors,well protecting graft lung and proper peri-operative treatment are the key steps leading to successful lung transplantation using grafts from organ procurement organization.
