Efficacy of different doses of levothyroxinein treatment of subclinical hypothyroidism in elderly patients and the effect on blood lipid level
10.7501/j.issn.1674-6376.2017.08.020
- VernacularTitle:不同剂量左甲状腺素治疗老年亚临床甲状腺功能减退症疗效评价及对血脂的影响
- Author:
lin Bao FU
1
;
Xing FU
Author Information
1. 旬阳县医院内科
- Keywords:
subclinical hypothyroidism;
levothyroxine;
dose;
efficacy;
blood lipid level
- From:
Drug Evaluation Research
2017;40(8):1134-1137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of different doses of levothyroxine in treatment of subclinical hypothyroidism and its effect on blood lipid level.Methods 98 cases of subclinical hypothyroidism elderly patients accepted in our hospital from March 2013 to May 2016 were divided into group A and B with 49 patients in each.The two groups were treated with different doses of levothyroxine treatment for 6 months.Then the clinical efficacy,thyroid function,blood lipid levels and adverse reactions of two groups were compared.Results The cure rate and total effective rate of group A were 59.18％ and 87.76％ respectively.The cure rate and total effective rate of group B were 61.22％ and 91.84％ respectively.There was no significant differencebetween two groups.After treatment,thethyroid function and blood lipid levels of two groups were better than before treatment.After 4 weeks of treatment,the thyroid function and blood lipid level in group B were better than those in group A (P ＜0.05).There was no significant difference in thyroid function and blood lipid between the two groups after 12 weeks of treatment.The incidence of total adverse reactions in group A was 4.08％,which was significantly lower than that in group B (16.33％),the difference was statistically significant (P ＜ 0.05).Conclusion Different doses of levothyroxine in the treatment ofsubclinical hypothyroidism were similar,and the thyroid function and blood lipids levels were improved after treatment,but the adverse reaction rate of low dose group was less.
