Research progress on solid dispersion technique in preparative field
10.7501/j.issn.1674-6376.2017.08.030
- VernacularTitle:固体分散技术在制剂领域的研究进展
- Author:
wei Jia TAN
1
;
yu Ru SUN
;
ling Yan ZENG
;
ying Shou DU
Author Information
1. 北京中医药大学
- Keywords:
solid dispersions;
solid dispersion technique;
insoluble drugs;
carrier materials;
preparation techniques;
stability
- From:
Drug Evaluation Research
2017;40(8):1182-1188
- CountryChina
- Language:Chinese
-
Abstract:
Solid dispersions (SD) as a preparation of intermediates have played an important role in improving the dissolution of insoluble drugs and its bioavailability.SD technique is one of the most promising techniques to improve the dissolution and solubility of insoluble drugs,and the development of SD technique will promote the gradual perfection in preparative field.This review focuses on the carrier materials of SD,various new preparation techniques and their comparisons,application of solid dispersion formulations,and stability problems of SD.The factors influencing the stability of SD are described,and the effective measures to prevent the aging of SD are put forward.Finally,the review puts forward the practical suggestions of the solid dispersion technique.
