A clinical analysis of six patients with Brucella endocarditis and literature review
10.3760/cma.j.issn.0578-1426.2017.10.005
- VernacularTitle:布氏菌性心内膜炎六例临床特点分析并文献复习
- Author:
Ling LUO
1
;
Baotong ZHOU
;
Huanling WANG
;
Hongtao DOU
;
Taisheng LI
Author Information
1. 100730,中国医学科学院北京协和医学院北京协和医院感染内科
- Keywords:
Brucellosis;
Endocarditis,bacterial
- From:
Chinese Journal of Internal Medicine
2017;56(10):734-737
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the epidemiology and clinical characteristics of patients with Brucella endocarditis in order to improve the understanding and treatment of Brucella endocarditis.Methods The clinical data including demographic characteristics,clinical features,laboratory data,echocardiography,treatment and clinical outcome of 6 patients with Brucella endocarditis were collected and analyzed.Results In our database consisting of 211 brucellosis patients with positive blood culture,6 patients (2.8％) with Brucella endocarditis were selected from May 2007 to December 2016 in Peking Union Medical College Hospital.The age range was 25-55 years,among whom 5 patients were men.The majority were farmers and all patients reported the history of closely contact with livestock.All of them had fever and 3 of them had arthralgia.Four patients had aortic involvement (4/6) and 2 of them presented with symptoms of left ventricular failure at admission.Blood culture of Brucella and serum agglutination test of Brucella were positive in all of them.Combined antibiotics treatments were given to all patients.Valve replacement surgery was performed in four patients,among them,three patients well recovered,one lost.Among all the patients,four were followed up continually and other two were lost.Conclusions Brucella endocarditis has a predominance of aortic involvement and is prone to left ventricular failure.Early antibiotic treatment combined with valve-replacement surgery is effective to improve the prognosis.
