Safety evaluation of coenzyme Q10 on central nervous system
10.7501/j.issn.1674-6376.2017.07.008
- VernacularTitle:辅酶Q10中枢神经系统的安全性评价
- Author:
bo Hong YANG
1
;
di Qing SUN
;
Ying TAN
;
lang Hui LIU
;
Wei LIAO
;
hui Xin SHI
;
Min SU
;
lei Guang BAO
;
kun Jing WANG
Author Information
1. 云南省药物研究所
- Keywords:
coenzyme Q10;
central nervous system;
toxicity;
mice;
safety evaluation;
motor coordination ability;
spontaneous activity;
synergistic reaction
- From:
Drug Evaluation Research
2017;40(7):926-930
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of high-dose coenzyme Q10 on the central nervous system in mice,and to provide experimental basis for clinical safety evaluation.Methods Mice were randomly divided into vehicle control group,perillartine control group,positive control group (chlorpromazine or diazepam) and coenzyme Q10 low,medium and high dose groups (1.5,3.0 and 6.0 g/kg,equivalent to 75,150,and 300 times of clinical dosage,respectively).The corresponding drugs were ig given to mice with the volume of 40 mL/kg.The general behavior of mice was observed directly,the motor coordination ability was observed by rotating stick method,and Anymaze animal behavior video analysis system was used to observe the spontaneous activity of mice and synergistic reaction with sub-threshold dose of pentobarbital sodium.Results There were no significant differences in the general behavioral activity,and the number of spontaneous activity times,mean resident time,and ratio of sleeping were found in all coenzyme Q10 groups,compared with the vehicle and perillartine control groups.Conclusion High dose of coenzyme Q10 has no significantly toxic effect on the central nervous system in mice,which could provide a reliable experimental basis for further medication study and clinical application of high-dose coenzyme Q 10.
