Clinical effect, safety and influence on pulmonary function of different doses of simvastatin in treatment of COPD
10.7501/j.issn.1674-6376.2017.07.017
- VernacularTitle:不同剂量辛伐他汀治疗慢性阻塞性肺疾病的疗效、安全性及对肺功能影响
- Author:
ning Yan XUE
1
Author Information
1. 榆林市第二医院药剂科
- Keywords:
COPD;
simvastatin;
lung function;
life quality
- From:
Drug Evaluation Research
2017;40(7):963-966
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect,safety and influence on pulmonary function of different doses of simvastatin in treatment of COPD.Methods Totally 192 COPD patients accepted in The Second Hospital of Yulin from July 2015 to January 2016 were selected and randomly divided into groups A and B with 96 cases in each group.Patients in group A were given 40 mg/d simvastatin,and patients in group B were given 20 mg/d simvastatin.Then the clinical effect,pulmonary function,life quality and safety of two groups were compared.Results The total effective rates after 1 month treatment of group A and group B were 82.29％ and 70.83％ respectively,which had no difference between two groups.The total effective rates of group A after 3 months treatment (89.95％ vs 77.08％) and 6 months treatment (93.75％ vs 84.38％) were higher than that of group B,and the differences were significantly (P ＜ 0.05).The indexes of pulmonary function after 1 month treatment of two groups had no difference.The indexes of pulmonary function after 3 months and 6 months of treatment of group A were obviously better than those of group B,and the differences were significantly (P ＜ 0.05).The life quality of group A was better than group B,and the differences were significantly (P ＜ 0.05).The safety between two groups had no difference.Conclusion Simvastatin (40 mg/d) has good effect and safety in the treatment of COPD,which can improve the lung function and life quality and is worthy of clinical applications.
