Outcome of surgical intervention for non-small-cell lung cancer patients with pleural carcinomatosis first detected at thoracotomy
10.3760/cma.j.issn.1001-4497.2017.09.003
- VernacularTitle:术中发现胸膜转移扩散的非小细胞肺癌外科手术治疗效果
- Author:
Baoxing LIU
1
;
Yin LI
;
Haibo MA
;
Jianjun QIN
;
Yongkui YU
;
Haoran WANG
;
Shilei LIU
;
Guanghui LIANG
;
Ruixiang ZHANG
Author Information
1. 450008,郑州大学附属肿瘤医院胸外科
- Keywords:
Carcinoma,non-small-cell lung;
Pleural carcinomatosis;
Pleural effusion;
Malignant pleural nodule;
Surgical treatment
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2017;33(9):522-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the effects of surgical intervention on the prognosis in non-small-cell lung cancer patients with pleural carcinomatosis detected at thoracotomy.Methods Retrospectively analyzed clinical data from 54 patients who have unexpected malignant pleural nodules and/or malignant pleural effusions first detected at thoracotomy from January 2009 and December 2013.The effects of surgical intervention on the prognosis were also discussed.Results Sixteen cases had only biopsy,whereas 38 (70.4％) cases had primary tumor resection.The median survival time of 54 patients with pleural carcinomatosis were 23 months.The overall 1 and 5-year survival rates were 64％ and 18％,respectively.Primary tumor resection had significantly better outcome compared with biopsy(MST:respectively,24 vs 15 months,5-year survival rate 39％ vs 6％,P ＜0.05).Univariate analysis showed that primary tumor resection,no smoking history,lower T and N stage has favorable survival(P ＜ 0.05).Multivariate analysis showed that the best N stage(P =0.002) and adenocarcinoma(P =0.035) were favorable prognostic factors in these patients.Conclusion For patients with pleural careinomatosis first detected at thoracotomy,limited primary tumor resection may have survival benefits,lower T and N stage for them was associated with better survival.
