Quantitative analysis on contents of four alkaloid components in Calonyction muricatum by QAMS
10.7501/j.issn.1674-6376.2017.07.011
- VernacularTitle:一测多评法测定华佗豆4种生物碱
- Author:
Chao CHEN
1
;
jun Fu ZHOU
;
Qi SHAN
;
Jie HUA
;
Miao WANG
;
bin Wen HOU
Author Information
1. 天津医科大学,天津300070
- Keywords:
quantitative analysis of multi-component with a single-marker;
Calonyction muricatum (Linn) G.Don.;
alkaloid;
HPLC;
ipalbidine;
ipalbine;
ipalbidinium;
ipalbinium
- From:
Drug Evaluation Research
2017;40(7):938-941
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a method of quantitative analysis of multi-components by single marker (QAMS) for simultaneously determining four compounds in Calonyction muricatum.Method An HPLC method was developed as QAMS to determine ipalbidine,ipalbidinium,and ipalbinium in C.muricatum,using ipalbine as the intermal reference substance,the relative correction factor (RCF) of the three components was determined by HPLC with good reproducibility.Their contents in six batches of samples were determined by both extemal standard method and QAMS.Result No significant differences were found in the quantitative results of three alkaloid compounds in six batches of C.muricatum determined by external standard method and QAMS.Conclusion It is feasible and suitable to evaluate the quality ofcurcuma aromatic by QAMS.
