IL-33/ST2 axis in systemic lupus erythematosus in relation to chronic kidney injury and disease activity
10.3969/j.issn.1000-4718.2017.09.026
- VernacularTitle:IL-33/ST2比值与红斑狼疮肾脏慢性损伤严重程度的相关性研究
- Author:
bao Yong HUO
1
;
Yi TAO
;
ling Si CHEN
;
sheng Yi WANG
;
hui Can HUANG
;
hui Wen HUANG
;
hui Cheng HUANG
;
lian Shui YU
Author Information
1. 广州医科大学附属第二医院风湿免疫科
- Keywords:
Interleukin-33;
Suppression of tumorigenicity 2;
Alarmin;
Systemic lupus erythematosus
- From:
Chinese Journal of Pathophysiology
2017;33(9):1696-1702
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To elucidate the association between chronic kidney injury and interleukin-33 (IL-33;an alarmin)/suppression of tumorigencity 2 (ST2) in patients with systemic lupus erythematosus (SLE).METHODS:Serum levels of IL-33 and soluble ST2 (sST2) were assessed by ELISA in 50 SLE patients and 30 healthy controls (HC).RESULTS:The levels of IL-33 and sST2,and IL-33/sST2 ratio were significantly higher in SLE patients than those in the HC.The IL-33 and sST2 levels were positively associated with SLE disease activity index (SLEDAI),erythrocyte sedimentation rate (ESR),proteinuria and triglyceride,but negatively associated with complement C3.IL-33/sST2 ratio was positively associated with SLEDAI and estimated glomerular filtration rate (eGFR).Independent explanatory variables associated with high IL-33/sST2 included chronic kidney disease (CKD) staging and albumin (R2 =0.442),especially CKD staging.CONCLUSION:Elevated serum sST2 and IL-33 levels in SLE patients are correlated with disease activity and risk factors of kidney injury.IL-33/sST2 ratio may serve as a potential biomarker for chronic kidney injury in SLE patients.
