Neurobiological mechanisms of conditioned fear memory reconsolidation
10.3969/j.issn.1000-4718.2017.09.030
- VernacularTitle:条件性恐惧记忆再巩固的神经分子机制研究
- Author:
nan Hao LI
1
;
wei Hong SUN
;
Gang WANG
;
yu Yan WANG
;
zhi Neng JIANG
;
Lin SUN
Author Information
1. 潍坊医学院心理学系
- Keywords:
Post-traumatic stress disorder;
Conditioned fear memory;
Reconsolidation
- From:
Chinese Journal of Pathophysiology
2017;33(9):1718-1722
- CountryChina
- Language:Chinese
-
Abstract:
Post-traumatic stress disorder (PTSD) is a reactive mental disorder that occurs after an individual was exposed to a traumatic event,and the core of the treatment is the extinction of conditioned fear memory caused by stress.Fear memory is an incentive mechanism based on external stimuli that occupy a central position in the defense system.Traditional memory concept convinced that the original memory traces were in an unstable state when the memory was activated.This process is called memory reconsolidation.The research has proved the existence of the fear memory reconsolidation,but the specific mechanism of reconsolidation has not been clarified.The animal studies show that many brain sites and molecular mechanisms are involved in the process of fear memory reconsolidation.Understanding the underlying mechanisms of fear memory reconsolidation is conducive to the treatment of specific phobias and PTSD.This review summarized the brain structure and molecular mechanism of conditioned fear memory reconsolidation,providing a new direction for the in-depth study of conditioned fear memory reconsolidation and PTSD.
