Overview of current situation and future development of radiation biodosimetry study
10.3760/cma.j.issn.0254-5098.2017.10.015
- VernacularTitle:辐射生物剂量计的研究现状及发展方向
- Author:
Zhongwu LIN
1
;
Qi WANG
;
Zhidong WANG
Author Information
1. 军事医学科学院科技部
- Keywords:
Radiation biodosimeter;
Chromosome aberration;
γ-H2AX;
Molecular biomarker
- From:
Chinese Journal of Radiological Medicine and Protection
2017;37(10):799-804
- CountryChina
- Language:Chinese
-
Abstract:
Radiation biodosimetry is an important part of radiation medicine. Some new discoveries and progresses have been made in radiation biodosimetry studies in recent years. Cytogenetic method represented by chromosome aberration analysis as the golden standard of radiation biodosimeter is being transformed to automate analysis, and a number of international, regional and national laboratory networks of radiation biodosimetry are being established. As a widely acceptable molecular marker of DNA damage,γ-H2AX has made rapid progress in radiation dose estimation. Based on the expressions of protein and genes, further advancements have been made in the studies of metabolites and miRNAs. At the same time, with the development of proteomics technology, there are some breakthroughs in the study of using molecular expression profiling to evaluate radiation dose. The research progresses of radiation biodosimetry is reviewed in this paper.
