Comprehensive evaluation of total serum bilirubin, amplitude integrated electroencephalogram and brainstem auditory evoked potential and in combination on the early diagnosis of neonatal acute biliru-bin encephalopathy by receiver operating characteristic curve
10.3760/cma.j.issn.1673-4912.2017.09.011
- VernacularTitle:ROC曲线评价血清总胆红素、振幅整合脑电图和脑干听觉诱发电位对新生儿急性胆红素脑病的早期诊断价值
- Author:
Dan ZHAO
1
;
Danhua MENG
;
Qiufen WEI
;
Xinnian PAN
;
yan LI
;
Kaiyan SHEN
;
Liping YAO
;
Hongjuan BI
;
Wei TAN
;
Lianfang JING
Author Information
1. 广西壮族自治区妇幼保健院新生儿科
- Keywords:
Receiver operating characteristic curve;
Bilirubin encephalopathy;
Early diagnosis;
Neonates
- From:
Chinese Pediatric Emergency Medicine
2017;24(9):686-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the levels of total serum bilirubin(TSB),amplitude integrated electroencephalogram(aEEG) monitoring and brainstem auditory evoked potential(BAEP) individually and in combination for the early diagnosis of neonatal acute bilirubin encephalopathy by receiver operating charac-teristic( ROC) curve. Methods Clinical data was retrospectively analyzed. A total of 152 infants were diag-nosed with hyperbilirubinemia,including 119 cases of non-bilirubin encephalopathy group and 33 cases of bil-irubin encephalopathy group. The detection results of peak serum bilirubin,aEEG,BAEP combined with the three methods were determined with ROC curve analysis. Results The areas under ROC curve of TSB lev-el,aEEG,BAEP and in combination were 0. 900,0. 738,0. 767,0. 925,respectively,the corresponding sensi-tivity(specificity) in the cut-off point were 90. 91%(78. 15%),87. 88%(59. 66%),65. 52%(87. 91%), 93. 10%(82. 42%),respectively. It showed that the area under ROC curve of the maximum,the comprehen-sive assessment in diagnostic sensitivity and specificity of the combination of three methods were better than any single detection method by ROC curve. Conclusion The methods of TSB level,aEEG and BAEP play an important role in the diagnosis of neonatal bilirubin encephalopathy,and combination with the three meth-ods can improve the accuracy of diagnosis.
