Change of Cerebral Blood Flow Distribution and Vascular Reserve according to Age in Koreans Measured by Tc-99m HMPAO Brain SPECT.
- Author:
Dae Hyuk MOON
;
Hee Kyung LEE
;
Ho Cheon SONG
;
Jaetae LEE
;
Hee Seung BOM
;
Hye Kyung SOHN
;
Hwan Jeong JEONG
;
Jung Jun MIN
;
Ji Yeul KIM
- Publication Type:Original Article
- Keywords:
Cerebral blood flow;
Cerebrovascular reserve;
Acetazolamide;
Tc-99m HMPAO;
Brain;
Singlphoton emission computed tomography;
Normal control study
- MeSH:
Acetazolamide;
Adolescent;
Basal Ganglia;
Brain*;
Cerebellum;
Child;
Female;
Frontal Lobe;
Healthy Volunteers;
Humans;
Male;
Occipital Lobe;
Parietal Lobe;
Perfusion;
Rabeprazole;
Reference Values;
Technetium Tc 99m Exametazime*;
Tomography, Emission-Computed, Single-Photon*;
Volunteers
- From:Korean Journal of Nuclear Medicine
1999;33(3):247-261
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to evaluate the normal values of regional cerebral blood flow (rCBF) and cerebrovascular reserve (CVR) in normal children to aged volunteers using Tc-99m HMPAO. MATERIALS AND METHODS: Thirty four right-handed normal volunteers (20 males, 14 females, mean age 40.3+/-24.9 years, range 4 to 82 years) were underwent rest/acetazolamide (ACZ) brain SPECT using Tc-99m HMPAO and the sequential injection and subtraction method. rCBF was estimated on the basis of a semiquantitative approach by means of right/left ratio, region/cerebellum and region to whole brain ratios in frontal, parietal, temporal, and occipital lobes, basal ganglia, thalami, and cerebellum. CVR was measured by means of % perfusion increase calculated as % mean count change compared to rest rCBF in each regions. RESULTS: Mean values of right to left ratios range from 1.004 to 1.018. rCBF was highest in cerebellum and lowest in basal ganglia and thalami. Frontal and temporal rCBF decreased while occipital and thalamic rCBF increased according to age. No sexual difference of rCBF was noted. Mean CVR was 29.9+/-12.9%. Mean CVR significantly increased to late teens, and declined thereafter. After 6th decade, CVR in both frontal lobes, left parietal lobe and right basal ganglia decreased significantly with advancing age. There was no sexual difference of CVR. CONCLUSION:: Quantitative assessment of CVR was possible by ACZ Tc-99m HMPAO brain SPECT. It revealed that rCBF and CVR changed according to age in normal Korean volunteers. There was no sexual difference.
