A Clinical Study of Antihypertensive Effect of Fosinopril in Essential Hypertension.
10.4070/kcj.1993.23.5.723
- Author:
Seung Sik KANG
;
Si Wan CHOI
;
KI Nam PARK
;
Byeng Su KWAK
;
Yong Seok CHOI
;
Baeg Su KIM
;
Eun Seok JEON
;
Chong Hun PARK
- Publication Type:Original Article
- Keywords:
Essential hypertension;
Fosinopril
- MeSH:
Blood Platelets;
Cough;
Fosinopril*;
Heart Rate;
Humans;
Hypertension*
- From:Korean Circulation Journal
1993;23(5):723-729
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study was designed to evaluate the safety and the efficacy of fosinopril(Monopril(R)) in the treatment of mild to moderate essential hypertension. METHOD: Fosinopril(10mg) once a day was administrated as a starting dose in 20 patients with essential hypertension in the morning and a one step upward titration was performed(fosinopril 20mg once a day, after 4 weeks treatment). RESULT: After 2 weeks treatment with dose of 10mg, the systolic blood pressure(SBP) was decreased(183.8+/-28.5 vs, 161.5+/-25.9mmHg, p<0.05) and the diastolic blood pressure(DBP) was also decreased significantly(108.3+/-9.3 vs, 96.6+/-10.3mmHg, p<0.05). The effect of fosinopril were maintained. The SBP an DBP were decreased in 14 out of 20 patients till 8 weeks. There was no significant change in heart rate before and after fosinopril treatment(74.3+/-10 vs, 76.4+/-7.9beats/min). Fosinopril had no significant effects on laboratory findings such as serum creatinin, BUN, AST/ALT, WBC, Platelet and lipid profiles. Mild dry coughing was noticed only in 5 patients and it did not disturb continuing medication. CONCLUSION: Fosinopril is an effective antihypertensive agent, as monotherapy once a day in patients with mild to moderate hypertension.
