A Clinical Study on the Hypotensive Effect of Captopril(Capril(R)).
10.4070/kcj.1993.23.5.730
- Author:
Yung LEE
;
Young Bak KOH
;
Kyu Hyung RYU
- Publication Type:Clinical Trial ; Original Article
- Keywords:
Essential hypertension;
Captopril
- MeSH:
Blood Pressure;
Captopril;
Cough;
Creatinine;
Dysgeusia;
Edema;
Electrolytes;
Heart Rate;
Humans;
Hypertension;
Male;
Peptidyl-Dipeptidase A;
Urinalysis
- From:Korean Circulation Journal
1993;23(5):730-734
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: A clinical trial was done to evaluate the antihypertensive efficacy and side effects of captopril(Capril(R)), an angiotensin converting enzyme inhibitor, in patients with mild to moderate essential hypertension. METHOD: Captopril was given 25-50mg a day to 46 patients(mean age : 51.3+/-8.9 years, 21 males and 25 females) for 8 weeks. RESULT: The blood pressure dropped significantly in 2 weeks and well maintained throughout 8 weeks of study period(p<0.01). The mean pressure drop was 14.4/8mmHg at 8 weeks without any changes of heart rate. The blood pressure was not dropped in 13 cases(28.3%). There were no significant changes in CBC, urinalysis and blood chemistry(sugar, lipids, electrolytes, creatinine, protein, albumin, AST and ALT) during this trial. The side effects were observed in 20 cases(43.5%). The most frequent was cough(19 cases, 413%) and the others were dysgeusia, dry eyes and edema in each respectively. CONCLUSION: Captopril(Capril(R)) monotherapy with 25-50mg a day regimen was effective in patient with mild to moderate essential hypertension, but somewhat high episodes of cough were observed in this trial.
