Study on the risk factors of chronic obstructive pulmonary disease in acute exacerbation complicated with pulmonary embolism
10.3969/j.issn.1673-4130.2017.20.011
- VernacularTitle:慢性阻塞性肺疾病急性加重合并肺栓塞血液相关风险因素分析
- Author:
Youxia LI
1
;
Hongman WANG
;
Maoxiang YANG
;
Shaohui FAN
;
Sha LU
Author Information
1. 遵义医学院第五附属(珠海)医院
- Keywords:
chronic obstructive pulmonary disease;
pulmonary embolism;
tissue factor
- From:
International Journal of Laboratory Medicine
2017;38(20):2829-2831
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the risk factors of chronic obstructive pulmonary disease (COPD) in acute exacerbation (AE-COPD)complicated with pulmonary embolism ,and to provide reference for the pathogenesis and treatment .Methods A total of 73 patients with COPD suspected PE admitted to our hospital from May 2015 to April 2016 were enrolled in this study .All patients were examined including WBC ,Neu% ,CRP ,IL-8 ,ESR ,PCT ,ET-1 ,D-dimer ,fibrinogen ,NT-proBNP ,myocardial enzyme ,arterial blood gas ,lactic acid ,CT pulmonary angiography(CTPA)within 48 h of admission .The risk factors of AECOPD with PE or with-out PE were analyzed .Results There were 15 cases with PE ,58 cases without PE in all objects .Neu% ,PCT ,NT-proBNP ,D-di-mer ,LDH ,cTnI ,CRP ,IL-8 ,ET-1 in patients with PE were significant higher than those in patients without PE (P<0 .05) .In the PE group ,the correlation coefficient between CRP and IL-8 was 0 .457(P=0 .087) ,the correlation coefficient between CRP and ET-1 was 0 .598(P=0 .019) ,the correlation coefficient between IL-8 and ET-1 was 0 .695(P=0 .004) .Conclusion Acute exacer-bation of COPD combined with PE is associated with the severity of inflammation in the body ,the more serious the inflammatory re-action ,the corresponding increase in myocardial injury ,the higher the risk of PE .
