Long-term Results for Sudden Cardiac Death Prevention of Implantable Cardioverter-defibrillator in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
10.3969/j.issn.1000-3614.2017.09.014
- VernacularTitle:致心律失常右室心肌病患者植入埋藏式心律转复除颤器预防猝死长期随访结果
- Author:
Kang YIN
1
;
Wei HUA
;
gang Li DING
;
qiu Yu LI
;
Han JIN
;
Min GU
;
Cong XUE
;
Shu ZHANG
Author Information
1. 北京协和医学院中国医学科学院国家心血管病中心阜外医院心律失常中心
- Keywords:
Arrhythmic right ventricular cardiomyopathy;
Defibrillator,implantable
- From:
Chinese Circulation Journal
2017;32(9):889-893
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare inherited cardiomyopathy,which may cause frequent ventricular arrhythmia or even sudden cardiac death (SCD).We observed the long-term follow-up result of high risk ARVC patients received an implantable cardioverter-defibrillator(ICD).Methods:We retrospectively collected ARVC patients with ICD who were treated in our hospital from 1996-12 to 2015-09 for their in-hospital and clinical records and conducted follow-up study.Results:A total of 39 ARVC patients were enrolled including 32 (82.1％) males,the mean age at diagnosis was (42.1±14.8) years and 33 (84.6％) patients suffered from persistent ventricular tachycardia (VT) or ventricular fibrillation (VF) prior to ICD therapy.The median follow-up time was 48.6 (32.3-73.3) months and 7 (7.7％) patients died during that period including 1 sudden death,1 heart failure and 1 cerebral infarction.28 (71.8％) patients received 540 appropriate ICD interventions,5 (12.8％) of them received the first appropriate ICD intervention more than 2 years after initial implantation procedure.12 (30.8％) patients experienced electrical storm and 7 (17.9％) of them with electrical storm more than 2 years after initial implantation procedure.The patients without broad precordial T wave inversion (TWI ≥V1～3) had a shorter eventfree survival period (HR=0.39,95％ CI 0.16-0.96).The application rates of antiarrhythmic drugs and radiofrequency catheter ablation before ICD therapy were similar in patients with or without appropriate ICD intervention,P＞0.05.Conclusion:High risk ARVC patients have frequent ventricular arrhythmia,ICD therapy could effectively stop VT/VF,which was the most reliable method to prevent sudden cardiac death.
